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September 25, 1878: Dr. Charles Drysdale, senior physician to the Metropolitan Free Hospital, writes an article in The Times newspaper in Britain warning against the ill effects of tobacco use. In it he pointed to "the enormous consumption of tobacco in all European states" and estimated that £15,000,000 was spent annually in Great Britain on tobacco. He concluded: "The use of tobacco is one of the most evident of all the retrograde influences of our time." Years earlier, in 1864, Drysdale had published the results of reasearch into excessive tobacco use in a medical journal, documenting cases of jaundice and "most distressing palpitation of the heart" in a young man who smoked ½ oz daily.